Methadone is frequently used as an analgesic drug for dogs although there are very few studies describing the pharmacokinetics of methadone in this species. In man methadone has a long half-life and there are considerable differences in pharmacokinetics between individuals. The dose interval is lengthened when the drug is used fore longer periods of time due to prolonged half-life. Therefore the drug dose must be adjusted individually. The purpose of this study was to study the fundamental pharmacokinetics of methadone in dogs, and to find an optimal drug dosage.

The demand for animal products has increased in the last decades, especially for poultry and pork. Pork production has increased drastically globally, and also in Uganda. Thirty-one percent of Uganda´s population lives in poverty. Pig production is believed to play a crucial role in poverty alleviation, because of the ability to convert low quality feed into high quality protein together with high reproductive potential. African swine fever (ASF) is a lethal disease of domestic pigs often characterized by haemorrhagic fever and with mortality rates up to 100%. The disease is endemic in most sub-Saharan countries and since 2007 in the Russian Federation and Caucasus area.

Oestrus in dairy cattle has changed over the last decades, the duration has decreased and the intensity of oestrus has declined. A possible explanation can be their high and increasing milk production. Heifers ability to show oestrus is probably not affected to the same extent. The aim of this study was to estimate and compare oestrus duration and strength in heifers of the Swedish Red and Holstein breeds. Standing oestrus has been the primary oestrus sign during many years.

In this final thesis, an existing method for analysis of chlorophenols (CP) in bottom sediments has been updated and adjusted for analysis of chlorophenols in soil. The covalent bonds between the chlorophenols and the soil matrix were broken through basic hydrolysis and the chlorophenols were then separated from the water phase through addition of sulphuric acid followed by ether extraction. The chromatography was improved through extractive acetylation of the chlorophenols.The updated method was then applied on soil samples from a contaminated area (a former sawmill in Hyttsjö, Östergötland, Sweden).The analyse was preformed by GC/MS with respect to 2-MonoCP, 4-MonoCP, 2,4-DiCP, 2,6-DiCP, 2,4,6-TriCP, 2,3,4,6-TetraCP and pentachlorophenol (PCP).Contamination of chlorophenols in nature can be explained by the former use of wood preservative chemicals based on chlorophenols. In the 1960s and the 1970s these chemicals were used in Sweden, but due to their toxicity they were banned by the Swedish government in 1978.In Hyttsjö a pentachlorophenol-based product named Santobrite was used for several years. The concentration of PCP in the soil samples from Hyttsjö varied from 0.2->1.8 ng/mg dry substance.

This study describes what impact activity within Wifstas, Matfors,Grönstas and Nolbys water protection areas have on the quality of the drinkingwater. It considers the use of the area, environmentally dangerous activitiesin the past and present, the geology?s part, what harm hydroelectric power damsmay cause if they break and how climate change might affect the area in thefuture. It also takes into consideration activities outside the waterprotection areas which might have a suspected impact on the water quality. Theresults of the study are that pollution from infrastructure such as roads, orwastewater from treatment plants may cause occasional contamination of thedrinking water, foremost due to flooding.

AbstractTitle: Does supplementation with omega 3 improve oxygen uptake among athletes?Author: Jonna Gustafsson and Maria Bohlin Nygren Supervisor: Frode Slinde Examiner: Ingrid Larsson Programme: Programme in dietetics, 180/240 hp Type of paper: Bachelor?s thesis in clinical nutrition, 15 hp Date: May 26, 2015Background: Previous research has shown that omega 3 fatty acids may improve cardiovascular functions by decreased aggregation and increased red blood cell deformability. This produces an increased blood flow and could have a potential effect on oxygen uptake. Optimal aerobic capacity is a determinant factor of performance within endurance exercise.Objective: To compile scientific research of the possibility that omega 3 supplementation could improve oxygen uptake among athletes.Search strategy: The literature research is based on searches in PubMed and Scopus with the terms ?Physical Endurance?, ?Oxygen Consumption?, ?Fatty Acids Omega 3?, ?Dietary Supplements?, ?Exercise?, ?Fatty Acids Essential?, ?Docosahexaenoic Acids?, ?Eicosanoic Acids?, ?Fish Oils?, ?oxygen consumption?, ?maximal oxygen consumption?, ?VO2 max?, ?athlete?, ?omega-3 supplementation?, ?physical endurance?, ??-3?, ?omega-3?, ?Maximal Aerobic Power?, ?Oxygen Uptake?, ?VO2? and ?Maximal Aerobic Capacity?.Selection criteria: Randomized controlled trials (RCT) with an intervention of omega 3-supplementation during three weeks or more were included.

Thermography is the assesment of the surface temperature of the horses body and it falls into the categori of physiological imaging. Thermography allows us to portray inflammation and changes in sympathetic tone in a graphical manner. The purpose of this study was to review thermography in equine medicine and to evaluate thermography as an aid in the diagnosis of lamness in horses. Thermography has been helpful to identyfy sprains, stress fractures, shin splints and soft tissue, tendon, ligamentous and nerv injuries and to monitor healing processes during rehabilitation. Routine thermography may reveal inflammatory responses prior to clinical signs. In present study thermograpy gave especially valuabel information in two cases. In one horse reduced blood flow in a. saphena due to a thrombosis were visualised and in the other horse bilateral thoracolumbal radiculopati was diagnosed.

Emerging infectious diseases are a recurring threat to both human and animal health. Understanding the multiple causes behind the emergence of new diseases is key to the prevention of new and potentially devastating outbreaks. The list of underlying causes is long, including a variety of anthropogenic, environmental, molecular and climatic changes that promote the emergence and spread of disease. Two of these factors are central to the emergence of new diseases and receive special attention in this study. The spread of disease from wildlife to livestock and diseases that spread from animals to humans (zoonoses) are of importance as they implicated in the majority of EID events.

The aim of the study was to test whether or not menstruating women?s levels of haemoglobin changed after three weeks consumption of Blutsaft. Previous studies on nutrition supplements including iron have shown increased haemoglobin levels. On Blutsaft, however, there are no studies carried out and published. The participants in this pilot study were menstruating women, with haemoglobin levels between 105 and 125 g/l at the initial part of the study.

Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

The aim of this study was to examine the current and historic mercury(Hg) load of the lake Storjuktan due to its recent exposure to a local potential source of Hg in form of the Sulphide mine Blaikengruvan(2006) and an earlier potential sources of Hg-load, the damming of the lake(1960s). Sediments were extracted using a HTH-sampler, freeze-dried, and analyzed for tot-Hg, LOI and activity of 210Pb and compared to samples extracted prior to the opening of the mine(2006). Constant initial concentration (CIC)-dating model was used for dating the samples. Low levels of Hg (100ng/g) were found throughout the lakes sediment. The highest levels of Hg(220ng/g) was detected at a depth of 4-5cm dating back to the mid 1970:s, suggesting that increased levels of atmospheric Hg rather than damming of the lake has caused the increase of Hg.

This report is about the development of a prototype of a mobile application and a web application that will help diabetes patients in their own treatment and ease diabetes nurses work with their diabetes patients. The mobile application is a digital version of a diabetes diary used by the Örebro County Council primary care to ease in diabetes treatments. The report also covers tests with users which were conducted on potential users to get some sort of feedback from groups other than customer and colleagues. Tests with users showed that there was an interest in a mobile application and it was a highly appreciated project. The web application ease diabetes nurses in their work with their diabetes patients in the way that the web application can display graphs of the patient's blood glucose level. .

Inledning: Distriktssköterskor har ett stort ansvar gällande blodtrycksmätning samt uppföljning av patienter med risk för hypertoni eller som behandlas för hypertoni inom primärvården. Blodtrycksmätning är en undersökningsmetod som förutsätter att den utförs korrekt med hänsyn till felkällor och rätt förfarande för att mätvärdet ska kunna tolkas rätt. Det finns ett flertal olika riktlinjer för hur standardiserad blodtrycksmätning bör utföras. Att arbeta hälsofrämjande är grundläggande i distriktssköterskors förhållningssätt och samtal kring livsstilsåtgärder är en viktig del i samband med behandling och förbyggande av förhöjt blodtryck. Syfte: Syftet med studien är att kartlägga hur blodtrycksmätning går till vid besöket hos distriktssköterskan samt vilka aspekter som tas upp i samtalet i samband med besöket.