Mammary tumors are the most frequent type of tumors in Bitches in Sweden. Many studies have been published concerning mammary tumors, but there is still much to be learned about this disease. One has, since some time ago, had the knowledge that addition to or removal of methyl groups to genes can inhibit or activate gene-expression. Methylation and demethylation is a normal phenomenon in the body and it is essential for the development and survival of the individual. The risk of developing a tumor disease is increased if the global methylationstatus is changed; if oncogenes demethylates (activates) or if tumor suppressor genes methylates (inactivates). In the human medicine one has seen that there are differences in methylationstatus between different tumors. In this study tumor and normal tissue from ten dogs were examined with regard to methylationstatus.

In Sweden, the most common way to castrate a bitch is by midline approach. In this study, flank and midline approaches are compared in order to evaluate incision by the flank as an alternative technique for ovariohysterectomy in the bitch. The study was performed on straydogs in the central part of Thailand under field conditions. 32 Bitches were included in the study. The castration technique was by flank and midline approach, alternating with every other bitch.

This article presents a retrospective case study combined with a review of the current literature concerning canine gestational diabetes. A total of 14 cases have been collected from six different clinics in Sweden. There are few previously published reports on canine gestational diabetes. Gestational diabetes is a disease that rarely occurs in pregnant Bitches. The condition is due to the rise of progesterone that occurs during the estrus cycle.

The female dog has a unique reproductive endocrinology, with high levels of progesterone throughout the 70-day long luteal phase. In this project, markers of glucose metabolism were studied and compared from the aspects of breed group and time in oestral cycle. The parameters studied were: glucose, insulin, progesterone, fructosamine and the newly introduced analysis of HbA1c. Hba1c was also further evaluated and discussed as a diagnostic tool in canine medicine.No differences in terms of glucose markers were found between a group of purebreed dogs of various breeds compared to a group of dogs with high risk of dioestrus diabetes, namely the Norwegian and Swedish elkhounds.No differences were found between the two sample occasions, anoestrus and dioestrus, concluding that there is no need for relating test results to the time of the oestrous cycle in middle-aged intact female dogs.There were statistically significant higher values of all glucose markers in diabetic dogs than in non-diabetic dogs. When it came to HbA1c, however, there was a larger overlap between the two groups, compared to fructosamine.

This study has been made to evaluate if there is a significant difference between non-estral intact versus ovariohysterectomized queens in their production of estradiol after exogenous gonadotrophin-releasing hormone stimulation. The purpose is to find a tool, which can help to diagnose if a free-roaming queen is already ovariohysterectomized or not. There are also other situations where this tool could be useful, for example to diagnose the ovarian remnant syndrome. Previous studies in Bitches have shown that GnRH-stimulation is an excellent tool to diagnose the presence of ovaries in the bitch. Eleven ovariohysterectomized and eleven intact queens have been included in this study where we have analyzed plasma estradiol and progesterone concentrations before and after a single intramuscular injection of the GnRH agonist buserelin (Receptal?).

This study is a follow up of a pilot study made 2004, that evaluated feeding, exercise and weight as possible risk factors for developing any kind of diabetes in dogs. We have selected our material for a certain kind of DM that exists among Norwegian and Swedish elkhounds. These breeds are among the most common breeds affected by diabetes and this kind of DM almost exclusively affects intact Bitches. We performed a case- control study where the owners were interviewed over the phone. The owners of a total of 48 case dogs and 58 control dogs were contacted. The questions for the cases focused on the time before the diagnosis and the questions for the control dogs focused on the dog´s adult life.

Exocrine pancreatic insufficiency is a hereditary disease that in Sweden is especially common in German shepherds. The Swedish German shepherd club has currently no plan of action for decreasing disease prevalence in the breed. The purpose of this study was to review existing literature about the disease and also to perform an inventory of the disease in the Swedish dog population. Special focus was laid on the German shepherd breed. The inventory was later compared to an unpublished inventory of the disease with data from the Swedish University of Agricultural Sciences from 1997. During the period 2002-06-01 to 2007-09-26 (ca 64 months) 2961 blood samples were analyzed for cTLI. 274 samples were positive (cTLI .

SAMMANFATTNINGDilaterad kardiomyopati (DCM) är en ärftlig, primär hjärtmuskelsjukdom som är mycket vanligt förekommande hos dobermann. Sjukdomens förlopp har tre stadier. Det första stadiet innebär att sjukdomen föreligger men kan enbart påvisas vid histologisk undersökning av hjärtmuskelvävnad. Det prekliniska stadiet innebär att inga sjukdomstecken ses hos hunden, men förändringar, såsom hög förekomst av kammarextraslag och dilatation av vänster kammare, kan hittas med hjälp av elektrokardiografi (EKG) och ekokardiografi. I det overta (kliniska stadiet) uppvisar hunden sjukdomstecken som nedsatt arbetsförmåga, trötthet, hosta samt kachexi.

Chronic valvular disease (CVD) is the most common cardiac disease in dogs, which account for 75% of all the cardiac cases. Cavalier King Charles spaniel (CKCS) is the most affected breed and it´s 13th times more likely that a CKCS, between the age of 7-10 years, will die or be euthanized for cardiac disease, compared with other breeds. The prevalence has been proven to bee independent of coat color and weight but highly dependent on age and gender in CKCS. In 2001 the Swedish Kennelclub and the Special club for cavalier King Charles spaniel created a breeding program against CVD in CKCS. In this program dogs are not allowed to breed until 4 years of age and have to have a heart auscultation without murmurs.

Working as a veterinary nurse includes advising animal owners, helping them to make discisions through well-based facts and experience. Preemptive spaying of the healthy bitch brings many advantages and disadvantages. It leads to cessation of gonadal hormone production, and how the exact extent the surgery affects the dog is not yet fully understood. The sex hormones mainly control the reproductive system, but receptors of these hormones are found in many tissues of the body, and have complex relationships with other hormone systems. Spaying decreases the metabolism although the bitch gets an increased appetite, which enhance the risk of obesity, unless the owner restricts food intake.

In 1996 a hunting test for British gun dogs was started in Sweden, based on a similar one al-ready in place in Norway. The aim of the new test was to describe the hunting ability of the dog and to use the results as a basis for selection. However, up to now, no genetic study of these data has been done. Therefore the aim of this study was to estimate genetic parameters for the traits measured in the hunting test and to investigate whether the traits can summarized into fewer overall measures. Data from trails of British gundogs between 1996 and 2005 in Sweden were used to estimate genetic parameters and environmental effects in hunting performance. British gundogs consist of five different breeds: Pointer, English setter (ES), Gordon setter (GS), Irish red setter (Irl S) and Irish red and white setter.