Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Purpose: The purpose of this thesis is to test for the existence of Capital Structure Arbitrage oppertunities in the equity-credit markets. Methodology: The mispricing of Credit Default Swap contracts are calculated and used as input in an Equity-Credit market trading strategy. The returns are then evaluated with a modified Value-at-Risk simulation. Theoretical perspectives: A Merton-based structural model, CreditGrades, is used for credit pricing and a mispricing-convergence trading-strategy between the credit and equity markets is implemented. Empirical foundation: Daily quotes for the Credit Default Swap spread of 37 European firms were collected for a period of two years, as well as equity-prices for the same period and the previous two years, used for model calibration.

Background: Operating on the stock market is associated with risks. If a particular asset is not traded with the same frequency as the average market asset, this particular asset is exposed to a liquidity risk. It means that the investor might not be able to sell the asset at a desired time without incurring expensive transaction costs. The query is whether or not the investor is compensated with a liquidity premium for bearing the extra risk. Earlier studies on the Stockholm Stock Exchange have failed to prove that there is a relation between stock return and liquidity.

Syftet med rapporten a?r att beskriva hur fastighetsbolaget, Varbergs Fastighets AB och energibolaget, Halmstad Energi och Miljo? hanterar de risk-, och osa?kerhetsfaktorer som fo?rekommer vid solcellsinvesteringar.Fo?r att energisamha?llet skall na? en ha?llbar framtid kra?vs att elproduktionen kommer ifra?n fo?rnybara energika?llor. Sedan a?r 2008 har installationstakten fo?r solceller i Sverige o?kat. A?r 2012 installerades 8,3 MW solceller och a?r 2013 mer a?n fo?rdubblades den installerade effekten till 19 MW (Lindahl, 2014).

The thesis is based on a case study of a Swedish discussion forum where survivalism and prepping is the main focus. The awareness of an abrupt and immanent breakdown together with a full and thorough preparation for any conceivable threat posed by that breakdown is what legitimizes survivalism and prepping. This preparation, or risk-proofing is 1) grounded in an isolation of the body and its predispositions from perceived risks, and 2) actualized through artefacts, theoretical and practical knowledge and awareness. Stories of the embodied survivalist are also stories of masculine and heterosexual subjects and ?the others?.

The financial crisis in 2008, effected companies around the globe and forced them to change their operational strategies, in order to survive. Companies with international links needed to consider external effects and due to that adapt their strategies on a global level. Demands for goods and service were decreasing and companies could only manage the cost during a recession to not face bankruptcy. Organisations need to reconsider their optimal strategy as this will determine their future outcome when managing a crisis as the one in 2008. British Airways - Air Cargo is a global company with an international network which serves about 80 countries, with about 200 destinations.

Specialarbete, 15 hpSvenska som andraspråk, fördjupningskurs SSA133Vt 2012Handledare: Hans LandqvistExaminator:.

Datum: 2009-06-02Nivå: Magisteruppsats i ekonomistyrning, 15 hpFörfattare: Charlotta Lind och Martin SlobergTitel: Ditt företag kan inte förutse konkurs -kan Z-score?Handledare: Esbjörn SegelodProblem: Våra forskningsfrågor är:Går det att förutse konkurs tre, fyra respektive fem år innan          konkursbeslutet?Vilka av den senaste Z-scoremodellens fyra nyckeltal är viktigast vid           prognostisering av konkurs?Syfte: Att testa i vad mån Z-scoremodellen kan användas för att förutse konkurserbland icke börsnoterade, icke tillverkande företag tre, fyra respektive fem årinnan konkurs; samt att undersöka vilka av denna modells inbördes nyckeltalsom är viktigast vid predicering av konkurser.Metod: Vi har genom kvantitativ metod analyserat årsredovisningar från 51 företagsom gått i konkurs 2008, dessa utgjorde vår huvudundersökningsgrupp och 29slumpmässigt utvalda företag, vilka utgjorde vår kontrollgrupp. Analysenskedde genom användandet av Altmans vidareutvecklade modell för attförutspå konkurser från år 1995. Totalt analyserades på detta sätt 240årsredovisningar.Slutsats: Modellens träffsäkerhet för de undersökta konkurs företagen var2003 45,09 %2004 47,05 %2005 54,90 %Vid hypotesprövning kunde vi endast för år 2005 påvisa samband förföretagsklassificeringsfrekvenser mellan konkursföretagen ochkontrollgruppen, detta gör att modellens prognostisering bör anses alltförosäker tidigare än tre år innan konkurs. Mot bakgrund till de påvisadeträffsäkerheterna för åren och hypotesprövningarna anser vi att modellenendast bör användas i kombination med andra analysformer .Sammanfattningsvis är Z-scoremodellens prognostiseringsförmåga för svag attsjälvständigt förutse konkurser.Sökord: Konkurs, Z-score.

This essay analyses the European Food Safety Authority's (EFSA) legitimacy. Theories on input- and output legitimacy are used in the examination. After analysing stakeholder representation, forum for deliberation, transparency, independence, and information sharing, input legitimacy in EFSA is assessed to be high. Output legitimacy was examined through the authority's outcome effectiveness, which was divided into compliance and effectiveness. Since food safety is an immense area, two important parts were chosen for the analysis of output legitimacy; transmissible/bovine spongiform encephalopathy (TSE/BSE) and genetically modified organisms (GMO).

The objective of this essay is, from the golf perspective including the golf courses' physical attributes, golf club management, members of the golf club and golf course designers, to explore possibilities for making existing golf courses more multifunctional. The purpose of this is to increase the understanding for golf courses' role as part of the landscape and comprehension regarding possible opportunities around them to exploit and develop.The increased pressure of population in peri-urban areas has resulted in a greater need for accessible recreation, particularly in the isolated farmland. As a result, land is sometimes used against landowners' will, which is a deficiency that is the basis for many conflicts between farmers and landowners.In the current situation, there is a negative trend in golf with reduced interest and fewer golfers than in the past. As a result, many of Sweden's golf courses have financial problems and are therefore trying to find new ways to avoid bankruptcy. Sweden's existing golf courses occupy about 30 000 hectares of land, of which a very large percentage are located in peri-urban areas.

Using leaching test is a way to get a picture of pollutants retention and leaching in a risk assessment on contaminated land. There are several different types of standardised leaching tests today, where the natural leaching processes are speeded up to make it possible to predict the leaching of pollutants. These leaching tests have been developed for waste and there are no specific guidelines on how to judge the results from the tests, when making a risk assessment on contaminated land. This work is an investigation on how to use leaching test in this type of risk assessments. The strengths and weaknesses of the different types of tests are discussed. Depending on what type of information you want from your leaching test, different types of tests are suitable.

The purpose of this paper was to investigate how teachers work to lead and motivate high-performing students, and how these students were defined. The method used was qualitative, more specifically an interview, which was then analyzed with a thematic analysis. Six teachers participated in the survey, and what emerged was that high-performing students were often ambitious, structured and social students. High performing students were also characterized by the fact that they needed challenges, attention and positive feedback on their performances, otherwise they ran a risk of not performing. Structure was also important for the teachers themselves, that they had a goal when teaching and a way of achieving that goal.

Small business enterprises have escalated in Sweden during the last decade. However, new established companies are struggling to maintain their selves during the startup process and according to a survey from Tillväxtanalys, only 68 % of startup companies from 2008 were still active three years later. One of the main reasons is lack of capital and the most common approach to finance companies is to apply for a bank loan. In other words, commercial banks are of great importance for new businesses. Although, the problem arises when there is no previous history from the new businesses that the bank could base its credit assessment on.

Bakgrund: Undernäring hos äldre är vanligt förekommande. Orsakerna till undernäring är många och leder till ökad risk för komplikationer och minskad livskvalité. Enligt tidigare forskning ansågs kunskap om undernäring och åtgärder brista och en avsaknad av riktlinjer identifierades. Syfte: Syftet med intervjustudien var att undersöka sjuksköterskors upplevelse av nutritionsbedömningar, dess åtgärder samt uppföljning för vårdtagare i risk för undernäring på särskilt boende. Metod: Intervjustudie med sex sjuksköterskor i en kommun i sydvästra Sverige.

Sammanfattning.Bakgrund:Crush syndrome eller traumatisk rahbdomyolys är vanligt vid större naturkatastrofer som tex jordbävningar. Det kan också uppkomma när personer utsätts för tryck mot musklerna vid tex stroke, intoxikationer, byggnadsras, industriolyckor. Inom ambulanssjukvården i Sverige har vi inte någon behandlingsplan för detta tillstånd och därför kan det finnas en risk att dessa patienter inte får rätt omvårdnad.Syfte:Studiens syfte var att belysa ambulanssjuksköterskans omvårdnad vid risk för Crush syndrome.Metod:En litteraturstudie gjordes för att granska redan publicerat forskningsmaterial. Sökningarna gjordes i databaserna Cinahl och Pubmed. Fem artiklar inkluderades och innehållet analyserades med manifest innehållsanalys.Resultat:De patienter som riskerar att få Crush syndrom har följande symtom: skada på muskelmassa, förlängd kompression, komprimerad lokal cirkulation, puls >120 och onormal urinfärg.