The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

The pathogenic fungus Rhizoctonia solani causes major economic losses for potato producers in Sweden. The producers, as well as advisors, have reported possible increases in severity of R. solani when free-living plant parasitic nematodes are present and active. There are several examples in the literature of interactions between pathogens where one, or both species, support or increase the damage made by the other organism. These complexes are important to investigate and to be able to forecast, since even low incidences of fungi or nematodes may result in an interaction of significance.

etta arbete belyser det för hästnäringen stora problemet ekvina placentiter från en veterinärmedicinsk synvinkel. Ekvin placentit betyder moderkaksinflammation hos häst. De vanligaste orsakande virusen, EHV-1 och EVA, samt ett mykotiskt agens, Histoplasma, tas upp. Bakteriella placentiter är dock mycket oftare förekommande. Därför diskuteras inte bara de tre agens som är vanligast; Streptococcus zooepidemicus, Escherichia coli och Pseudomonas aeruginosa, utan även två bakteriella agens på snabb frammarsch; Leptospira spp.

etta arbete belyser det för hästnäringen stora problemet ekvina placentiter från en veterinärmedicinsk synvinkel. Ekvin placentit betyder moderkaksinflammation hos häst. De vanligaste orsakande virusen, EHV-1 och EVA, samt ett mykotiskt agens, Histoplasma, tas upp. Bakteriella placentiter är dock mycket oftare förekommande. Därför diskuteras inte bara de tre agens som är vanligast; Streptococcus zooepidemicus, Escherichia coli och Pseudomonas aeruginosa, utan även två bakteriella agens på snabb frammarsch; Leptospira spp.

Disinfection methods for drinking-water produced at the two water works of Stockholm Water Co are compared in this study. Three different nethods are compared; disinfection with chlorine gas, disinfection with sodium hypochlorite and disinfection with UV-light and monochloramine. The method used is Life cycle assessment, LCA. LCA is defined as the compilation and evaluation of the inputs, outputs and potential environmental impact of a product system shroughout its life cycle. The environmental burden is compared for the three different disinfection methods.

The biogas plant Kungsängens gård, owned by Uppsala Vatten och Avfall AB, produces biogas and biomanure from organic household waste, food processing waste and slaughterhouse waste. In year 2012, 4.4 million Nm3 of biogas were produced from 25 200 tons of waste. Before digestion all substrate is sanitized by pasteurization at 70°C in order to kill pathogens. Another method, integrated thermophilic sanitation (ITS), is of interest in order to decrease the energy demand. The method implies that the substrate is sanitized during ten hours in the digestion chamber, where the temperature is 52°C.

The biogas plant Kungsängens gård, owned by Uppsala Vatten och Avfall AB, produces biogas and biomanure from organic household waste, food processing waste and slaughterhouse waste. In year 2012, 4.4 million Nm3 of biogas were produced from 25 200 tons of waste. Before digestion all substrate is sanitized by one hour?s pasteurization at 70°C in order to kill pathogens. Another method, integrated thermophilic sanitation (ITS), is of interest in order to decrease the energy demand.

The estate of Rämningstorp in the region of Västergötland in southern Sweden is administered by the holding trust company Skogssällskapet i Skövde. In 1999 measures were taken by Skogssällskapet to drain the stream Fredstorpsbäcken as a means to increase the forest productivity of the surrounding lands, which are situated on the estate of Rämningstorp. Almost immediately after the drainage, the streamwater turned turbid and a landowner downstream reported the issue to the county administrative board of the region. The aim of this thesis was firstly to analyse the suspended matter that appeared during summer/autumn and secondly to explain why it came to be. Initial hypotheses for the explanation to the greyish turbid water were that it was either 1) a chemical/biochemical precipitate, or 2) an bacterial/algal blooming.

Sahlgrenska Academy at University of Gothenburg Department of Internal Medicine and Clinical NutritionAbstractTitle: Can probiotics prevent atopic dermatitis in children with high risk?Author: Laura Pienihäkkinen and Max OlinSupervisor: Heléne Bertéus ForslundExaminer: Anna WinkvistProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2012Background Allergic disease is today common, this including atopic dermatitis, which is the most common inflammatory skin disease in the world. Heredity has been shown to play a major role in the development of this disease. It is therefore of high interest for both the individual and society to find effective methods for preventing atopic dermatitis in individuals with high risk profile. Probiotics are beneficial for the bacterial profile in the intestine and it is therefore of interest to study if they through their anti-inflammatory effect could prevent atopic dermatitis.Objective The aim was to study whether administration of probiotics to the mother and the child (directly or via breast milk) could prevent atopic dermatitis in children with high risk profile (at least one first degree relative with a diagnosed allergic disease).Search strategy A systematic literature search was done in databases PubMed and Scopus with search terms maternal, prenatal, probiotics, allergy, atopic dermatitis, prevention, and children.Selection criteria Randomized, controlled human studies and original articles in English were included.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Wounds on horses are common and sometimes difficult to treat. The wounds are often big and could be discovered too late for primary sutures, which have to be applied within 8 hours from time of accident, before bacteria has been able to infiltrate the surrounding tissue. The healing is often complicated by delayed healing and wound infection with consequences like phlegmone, fistulation and proud flesh formation.To avoid these consequences, the traditional practice has been to administer systemic antibiotics alone, systemic antibiotics in combination with topical antibiotics or topical antibiotics alone. Because few antibiotics can be used in horses, is it important to household with the few substances that are available. In veterinary medicine today, the increasing resistance amongst pathogenic microbes such as MRSA presents a growing problem.

AbstractThe research project Liberation, supported by the European Commission under the Environment and Sustainable Development Programme (Fifth RTD Framework Programme) aimed at developing a decision support system for ecological risk assessment of contaminated sites has proposed a tiered system including the triad method. This method integrates contaminant chemistry and bioavailability analyses with observed ecotoxicological effects in soil and groundwater. In this study the triad method was used to perform a risk characterization of a former surface treatment and metal industry, now used for the student union buildings of the Mälardalen University in Eskilstuna, Sweden. On the site, high concentrations of copper, zinc and nickel have been detected in the soil in a preliminary investigation of contaminant levels with XRF. For performing the risk assessment of the site according to the triad method, contaminant bioavailability, soil metal concentrations and soil toxicity were determined and an ecological assessment was carried out on four selected soil samples (one reference soil and three samples with low (B), medium (C) and high (D) contaminant levels). Contaminant bioavailability was measured through leaching (ISO TC 190/S7) and biouptake tests (DGT).

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Problems with wild boars are increasing in Sweden and some people argue that the wild boar population must decrease. This is mostly the opinion by farmers, while the hunters want more wild boars in Sweden. Today the population is the strongest in the south of Sweden and in the eastern parts of the country. However the population is growing stronger in other parts of Sweden as well. The population origins from these areas where they escaped from pens around 1970.

As the world´s population increases and people's living conditions are improving, larger areas are needed for houses as well as food production. This means that new areas are exploited and that people, livestock, blood sucking insects and wild animals are forced to live close together. In combination with the global warming, leading to extreme weather such as floods and storms, this allows both new and old pathogens to emerge. The number of "emerging infectious diseases", EIDs, has increased in recent years and many of them have their origin in poor, tropical countries. Moçambique is therefore considered to be a high risk area for EIDs. Schmallenberg virus, SBV, was discovered in 2011 as an "emerging infectious disease" in dairy cows in Germany.