Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

Syftet med denna studie är att utifrån ett föräldraperspektiv undersöka behov av och önskemål om stödsom föräldrar med diagnos inom autismspektrum beskriver i sin föräldraroll. Ett annat syfte är att bidra med ökad kunskaptill en diskussion kring utformandet av stödinsatser för dessa familjer. Studien är kvalitativ med intervjuer som gjorts ihalvstrukturerad form. Åtta föräldrar har intervjuats. Föräldrarna beskriver att deras svårigheter gör det svårt för dem isamspelet med barn och partner.

The aim of this essay is to examine which help a group of women with eating disorders had from thier treatment in daycare in 2004. The aim is to examine how the women have experienced this treatment and how they live today. The central questions are: what was their life situation like before the treatment, what was their experience of the treatment, how could the treatment have been better and how are their lives today? The method is based on qualitative interviews with seven women who were all in the same treatment for eight weeks at Capio AnorexiCenter in Malmö. The women have also redone tests that were done right before and right after the treatment.

The E-department at GETRAG All Wheel Drive in Köping have problems with the efficiency on parts of their production equipment. The equipment with the most significant efficiency problems are four automated multifunctional production cells that produces housing for rear drive units. The major part of the problem is the large amount of small stops that causes the low efficiency.The department already worked with logging of interruptions and efficiency calculations before this project started. However this work was not done to the extent considered necessary for a systematic follow-up of the interruptions.The aim of this paper is to point out a more effective and systematic way to work with logging of interruptions and the follow-up. In addition the equipment were studied with a method for efficiency calculation that ? if used properly- is a more powerful and a visually better method than the one used by the company today.As the initial current state analysis of the equipment was made a lack of documented knowledge about the equipment was discovered.

Syftet med denna uppsats är att beskriva och analysera svenska myndigheters internrevision för att kunna dra slutsatser om i vilken ansvarslinje de befinner sig i dagsläget samt att föra en diskussion kring internrevisionens oberoende. I denna uppsats har en kvalitativ studie genomförts. Med hjälp av semi-strukturerade intervjuer på sex olika myndigheter med krav på internrevision har empiri insamlats som tillsammans med teoretisk referensram ligger till grund för analys och slutsatser. Studien visar att svenska myndigheters internrevision befinner sig i den tredje ansvarslinjen. Vissa variationer inom den tredje ansvarslinjen kan urskiljas på grund av dels otydliga riktlinjer för internrevisorerna för att kunna bibehålla ett oberoende i samband med råd och stöd och dels på grund av bristfälliga kunskaper i den andra ansvarslinjen avseende hur ansvaret ska fördelas. .

This report relate a concept study that consider a number of different proposals to improve the overcharging system in BAE Systems Ha?gglunds tracked vehicle series BvS10, to maintain sealevel power at extreme altitude.At high altitude the power losses beacuase of the air density that decreases, which results in less fuel can be burned. The decreasing of air density also gives rise to fatigue failure of the turbocharger unless power is reduced.The proposals shall be as required by BAE Systems Ha?gglunds economically sustainable and defensible from a packing perspective. That means the selected solution must have a reasonable price tag and at the same time a minimal impact on adjacent components.The basis for this thesis is based on benchmarking of both the auto industry as the flight industry, to find inspiration and tips for improvement.Some of the concepts have after gathering facts and calculations been excluded while other solutions has been considered as workable and thus interesting for BAE Systems Ha?gglunds.Initially the current turbochargingsystem was analyzed in order to determine the starting point and thus be able to fix the current problems surrounding high altitude driving.

Bakgrund: Hjärtsvikt är en kronisk sjukdom som blir allt vanligare i västvärlden, underliggande hjärt- och kärlsjukdomar är ofta bidragande orsaker till att hjärtsvikt uppstår. Sjukdomen har en allvarlig påverkan på kroppen och gör att personers hälsa sätts ur balans. Syfte: Syftet var att belysa upplevelser av att leva med diagnostiserad hjärtsvikt med minst NYHA II. Metod: En litteraturstudie har gjorts och baserats på 13 vetenskapliga artiklar. Resultat: Personer med hjärtsvikt upplever fysisk, social och psykisk påverkan på livet på grund av sjukdomen.

    AbstractThe aim of the study was to describe factors of nurse?s experiences when they give NIV treatment to patients with acute respiratory failure in a lung department. Semi structured interview questions about how nurses experience to give NIV treatment on a ordinary lung department was done on 10 nurses, who work in a lung department were NIV treatment is given. Data were analyzed with content analysis. In the result there was shown two themes.

A study of communication content, frequency and problems was performed at the Swedish Air Force Air Combat Simulation Centre, FLSC. The purpose was to investigate the connection between team communication and performance variables, to study communication problems during air combat and to employ and develop the PILOT method of communication problem analysis. Ten fighter pilots and four fighter controllers engaged in simulated air combat beyond visual range in teams on two sides, Blue and Red, with four pilots and one fighter controller each. Eight such training runs lasting 15 to 25 minutes were analyzed with regard to the Blue team?s communication during launch situations, i.e.

AbstractTrendanalys av rapporterade störningar vid de svenskakärnkraftverkenAnalysis of trends in reported safety-related events atSwedish nuclear power plantsSafdar KargarThis degree project was conducted at the Swedish Radiation Safety Authority (SSM)as part of the bachelors program in Nuclear Engineering at Uppsala University duringthe spring of 2011.The Swedish Radiation Safety Authority (SSM) has developed a Windows baseddatabase called ?ASKEN? during later years. In this database more than 12 000 eventreports are stored sorted in three categories, category 1, 2 and 3. The databasecontains events from the start of Oskarshamn 1 in 1972 till present time.All nuclear power plants in Sweden are obliged to report any deficiency in theirbarriers and/or the defense in depth in obedience to SSMFS 2008:1.When a failure is detected or there is reasonable suspicion of a deficiency, the eventreport should be classified as a deficiency of category -1, 2 or 3 [1].The event reports are logged and archived in the register of SSM. The SSM task forceAnalys av Störningar på elproducerande Kärnkraftverk (the ASK-group), evaluates allincoming event reports and categorizes them according to established criteria.The aim of the project is to study and analyze the event reports in the database andidentity interesting observations and trends which should be investigated morethoroughly by deeper analysis to establish any positive or negative trends of reportedevents. .

Patienter med hjärtsvikt är en stor patientgrupp som har ökat i antal då hjärtsjukvården förbättrats samt att medellivslängden har ökat i Sverige. Hjärtsvikt karaktäriseras av påfrestande symtom och påverkar både patient och anhöriga i deras vardag. För att individen ska kunna hantera sin livssituation behövs stöd ifrån både omgivningen och vården. Syftet med studien var att belysa betydelsen av stöd till patienter med hjärtsvikt. Metoden var en litteraturstudie innehållande totalt 13 vetenskapliga artiklar.

Problem: De flesta människor associerar entreprenörskap med framgång, vilket också är den bild som massmedia vanligtvis ger av entreprenörskap. Men att vara entreprenör är kopplat till risk, risk som ibland leder till misslyckanden som kan uppfattas negativt av samhället. Utifrån detta resonemang har vi intresserat oss för hur entreprenörer själva ser på misslyckande. Syfte: Syftet med uppsatsen är att öka förståelsen för hur entreprenörer ser på misslyckanden. Vår förhoppning är att detta ska inspirera till entreprenörskap genom att minska rädslan för misslyckande. Metod: För att uppnå vårt syfte och besvara vår frågeställning har vi utifrån tidigare forskning byggt upp en teoretisk referensram som vi sedan utgått från för att samla in empiriskt material. Detta har skett genom intervjuer med tre entreprenörer.

AbstractFor an audit organization, it is important to work toward maintaininga high error climate to handle errors in an efficient and propermanner. This means that it is important for accountants to worktowards high quality of work, reduce and manage errors that mayoccur in their daily work. Therefore, auditors must know how tohandle errors in order to improve efficiency, which can be affected byhow leadership is exercised in the workplace. The error climatemeans being able to act in a manner which will ensure a good jobtowards customers but also within the internal operations.The ethical leadership may thus have an impact on how auditorshandle the error environment both internally and externally. It is veryimportant for customers to have confidence in the business but also tomaintain the order and the general rules of society for accountingfirms.My study aims to show the thinkable relationship between ethicalleadership and the error climate.

Williams, E. 2003 Radiologic sign of lung oedema in the dog and cat. To determine if the descriptions of lung oedema in the literature accurately describe the presence and frequency of radiologic signs, thoracic radiographs of 55 dogs with mitral regurgitation due to endocardiosis (ME), 46 dogs with dilated cardiomyopathy (DCM), 9 dogs with hunting oedema, and 20 cats with hypertrophic cardiomyopathy (HCM) were analysed. The location, type (diffuse or patchy, without or with air bronchograms) and presence of pleural oedema, bronchial wall thickening, widened pulmonary veins, and heart enlargement with subjectively and by the VHS measurement, were determined, and analysed by chi squared test with respect to disease. The dogs nearly always had diffuse oedema, whereas 35% of the cats had a patchy pattern, which agreed with the literature. The common occurrence of cranioventral and caudioventral oedema in heart failure was not described.

Introduction: Balance between the essential nutritive substances is important for aperson to maintain health. The surgical patient can be stricken with conditions, whichhave a negative impact on this balance and can lead to malnutrition. Working as a nurseit is important to identify patients that are malnourished or is in the risk zone ofmalnourishment since 30 % of all patients in hospitals are malnourished.Aim: The aim of this study was to examine the compliance to the guidelines fornutritional assessment and parenteral nutrition on a surgical ward. Also whether thenutritional treatment/-support was reported to the next caregivers if the patient wasmalnourished or was in the risk zone of malnourishment at the time of discharge.Method: 80 patients enrolled on the ward in the beginning of year 2011 were included.Audit of patient records was made according to the hospital guidelines for nutrition andparenteral nutrition and followed a study specific protocol.Results: The examination of the case records showed that the guidelines for nutritionwere partly complied with. Nutritional treatment/-support was reported to the nextcaregivers when needed.