Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

This thesis aims to increase understanding and knowledge of issues affecting the redevelopment of older office buildings to housing. The rising demand for housing in recent years has resulted in a need and an increase in cost housing projects. The need has led property owners wanting to build old office buildings to apartments. The case study is carried out in Lycksele town and in close contact with consultancy TM (Technician Mercantile) ? consulting, which has operations in the area.

How capital structure influences corporate performance and value has been in the interest of researchers and scholars for more than half a century, but an answer is yet to be found. The main objective of the present paper is to contribute with data for this cause and hopefully help to clarify this mystery. The method that was used was by analyzing the impact of debt on profitability and market valuation through linear regression. The study examined 17 Swedish property companies listed on Nasdaq OMX Large Mid and Small Cap over a 6 year period (2007-2012). The authors found a slightly negative relationship between debt-to-equity and profitability measured by return on equity (ROE) as well as by return on assets (ROA).

Contents:The evolution of today?s computer influenced society has taken giant steps towards virtual reality, game addictions and the possibility of not having to meet the people we communicate with. What is a reality today?To give a more concrete image of our question we?ve chosen the online game World of Warcraft as an example and to describe our connection to an alternative reality. We have performed different investigations, interviewed both gamers and non gamers, all this to give us the opportunity to see if the term reality has started to change in a direction that will allow us to call this alternative world a reality, or if it?s just a world wide phenomena of for example gaming addiction.

This study discusses and examines the alternative teaching materials in religion class amongst seven teachers in Stockholm region. As religion is a complex subject to both learn and to teach it may be beneficial to use alternative texts to show the diversity of the subject. The aim of this study was to examine why teachers use news articles and other articles from daily magazines in their religion class. I also examined how the teachers motivated their choices of teaching materials. The study is qualitative and the empirical work was done by interviewing seven teachers in religion.

The work presented here aims to give the owners ofChâteau du Grand Val, Roland and Marie Nilssond?Aubigné an integrated creative forest management planin which their goals with the property is heeded, andwhere the plan is so clear that they can follow it withoutmuch difficulty.This work has come about through the normal processesof forest management plans, landscape architecturalproposals as well as through field trips, field andliterature studies, and our combined experience fromour studies. The study visits, both on location in Brittany,France, but also in other places, as for instance Högestad,has provided the background information that formedthe basis of our analysis and the proposal that is derived thereof. Some suggestions, which we consider importantto the overall impression of the property, is provided amore focused and detailed solution, while other parts,which are important but can either benefit from havingdynamics in the design process or will be adapted toadjacent sites, are developed using a more generalapproach. In some cases several possible developmentprinciples are presented.The proposal presents a detailed plan for themanagement of the forest from the experience, wildlifeand forestry economic standpoint.

Today's real estate buyers value the purchase different today compared to a decade back. Previously it was the return value that ruled the market. This has created problems when the broker must allocate the purchase price of the property's various elements, because non-monetary values such as forest for leisure, recreation, and the feeling of owing has increased in recent years and an increasingly important part in the valuation process. The assessed value can be a guide, but is perceived today to be stereotyped to put a fair value at the individual item. The purpose of this study was to provide the real estate agent decision support and a guide to the likely value of accounting for the purchase price. The report is written on behalf of LRF Konsult. The result is based on a questionnaire survey which was conducted in June 2014 among all those who had bought a farming property in Dalarna and Gävleborg province mediated by LRF Konsult in 2013. The report was made with a split to see if the valuation and motives differ between new and previous owners. It was possible to see a big difference in the reason for the purchase, where a large share of new owner bought the land for capital investment, in contrast to previous owners whose biggest group bought for an active use. At several points it was possible to identify a higher non-monetary value of the new owner from the previous landowner.

In Sweden, a big part of the energy use is used in the housing sector. Political goals and targets are set up which the housing sector needs to work towards. Apartment buildings are a major part of the housing sector in Sweden and therefore reduction of energy use in these kinds of buildings are key to lower the energy use in Sweden. But there are not only political incentives to reduce the energy use. Some energy?saving measures are directly profitable and should thus be performed.

Biogas is a renewable fuel that can be extracted from anaerobic digestion of many differentsubstrates, for example biological household waste. An alternative handling of the waste is tomix it with other wastes and incinerate it in a combined heat and power (CHP) plant. Thisstudy uses life cycle assessment to investigate which type of waste handling that is betterfrom an environmental point of view, anaerobic digestion with biogas production orincineration. The results are based on a case study of a biogas production plant owned by thecompany Ragn-Sells in Vänersborg. The alternative is incineration at a CHP plant inGothenburg.

The market value of forest properties can be assumed to consist of two components, a monetary factor and a non-monetary factor. The objective of this examination paper is to study the impact of non-monetary factors on the values of forest properties in Sweden. This study is based on a population of buyers of forest properties in the southern of Sweden. The results are based on interviews with 54 buyers. Of the purchases were 37 % new purchases.

The producers of grain in Sweden are facing a rough future. The competition is getting harder all the time, in Sweden, in EU and also from the ?world market?. The producers have to be more efficient and have to have bigger units. Many producers might have to look for new alternative production opportunities.

The purpose of this thesis is to examine the classification,shelf arrangement and display of documents in antiquarianbookshops and see the reasons behind these. The results willbe compared with previous reviews of alternative shelfarrangement in Swedish public libraries, to see whatdifferences and similarities there are in the classification andshelf arrangement between antiquarian booksellers andlibraries. The questions to be answered were: (1)What formsof classification and shelf arrangement are used inantiquarian bookshops and how does it differ from theclassification and shelf arrangement made in libraries withan alternative shelf arrangement? (2)What exposure ofdocuments are there in the various antiquarian bookshops? Isthere anything regarding the exposure that differs betweenthe antiquarian bookshops and the libraries? An idea andideology analysis of various dimensions is used as atheoretical tool during the work. The dimensions were: (1)Shelf arrangement: It is important that customers/borrowerscan find themselves - it is important that staff know wherethe documents are.

This literature review summarizes available data on infection with the parasitic roundworm, Ascaridia galli, as a cause of disease in poultry, including the consequences of a conversion to alternative production systems. Ascaridia galli has a direct life cycle with resistant eggs that survive and are easily spread in the environment, especially in systems with bedding materials where the faecal contact is high. The infection is usually subclinical but depending on the infection dose, the symptoms range from weight loss and diarrhea to mortality. Factors such as the feed composition and genetic variation among different hybrids clearly affect the establishment rate of the infection. Ascaridia galli will probably become an increasing problem, with a shift from the traditional battery cages to alternative systems where the risk of re-infection is high.

Because of increasing demand of power on Malmbanan the capacity of the existing wires which supply the trains must be increased. This increases the stress on the existing poles and for this reason the system for supplying the loads along the railway is to be removed from the poles and be replaced by some other system. This thesis is a study on a two-level low voltage (1 kV and 0.4 kV) electrical system with the aim to investigate if it can be an alternative to the system used today taking into account the voltages, fault currents and costs.In this thesis the following tasks have been performed:? Gathering of data? Description of basic theory? Loadow and fault current calculations of the system with MATLAB? Life Cycle Cost estimate of the system? Analysis and conclusions from the resultsThe results show that the new system can be an alternative to replace today's system. The simulations and calculations show that the voltage drop is at an acceptable level and that the fault currents are large enough to supply a safe disconnection if a fault occurs at the far end of the system..

The use of a bit in the mouth of a horse is being increasingly questioned with respect to its actual function, and is sometimes judged an obsolete instrument of control with potential to injure the horse. The objective of the research presented herein was twofold; firstly, to investigate the actual pressure load in the mouth of the horse with regard to oral health issues, and, secondly, to investigate whether this could be a viable method to objectively measure strength exerted by a rider/driver to the mouth of the horse especially with regard to training regimes. From the results, it is evident that these newly developed sensors have a future in equine research, although they are still under development. They can be useful both as a pedagogic teaching instrument, providing instructor and pupil with instantaneous, objective feedback on the contact between hand and mouth, as well as an aid in measuring pressure loads from our common bits. .