Alternative splicing is a process that partly rejects the common definition of a gene ? that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ER? and ER?, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer.

Contents:The evolution of today?s computer influenced society has taken giant steps towards virtual reality, game addictions and the possibility of not having to meet the people we communicate with. What is a reality today?To give a more concrete image of our question we?ve chosen the online game World of Warcraft as an example and to describe our connection to an alternative reality. We have performed different investigations, interviewed both gamers and non gamers, all this to give us the opportunity to see if the term reality has started to change in a direction that will allow us to call this alternative world a reality, or if it?s just a world wide phenomena of for example gaming addiction.

This study discusses and examines the alternative teaching materials in religion class amongst seven teachers in Stockholm region. As religion is a complex subject to both learn and to teach it may be beneficial to use alternative texts to show the diversity of the subject. The aim of this study was to examine why teachers use news articles and other articles from daily magazines in their religion class. I also examined how the teachers motivated their choices of teaching materials. The study is qualitative and the empirical work was done by interviewing seven teachers in religion.

Biogas is a renewable fuel that can be extracted from anaerobic digestion of many differentsubstrates, for example biological household waste. An alternative handling of the waste is tomix it with other wastes and incinerate it in a combined heat and power (CHP) plant. Thisstudy uses life cycle assessment to investigate which type of waste handling that is betterfrom an environmental point of view, anaerobic digestion with biogas production orincineration. The results are based on a case study of a biogas production plant owned by thecompany Ragn-Sells in Vänersborg. The alternative is incineration at a CHP plant inGothenburg.

The producers of grain in Sweden are facing a rough future. The competition is getting harder all the time, in Sweden, in EU and also from the ?world market?. The producers have to be more efficient and have to have bigger units. Many producers might have to look for new alternative production opportunities.

The purpose of this thesis is to examine the classification,shelf arrangement and display of documents in antiquarianbookshops and see the reasons behind these. The results willbe compared with previous reviews of alternative shelfarrangement in Swedish public libraries, to see whatdifferences and similarities there are in the classification andshelf arrangement between antiquarian booksellers andlibraries. The questions to be answered were: (1)What formsof classification and shelf arrangement are used inantiquarian bookshops and how does it differ from theclassification and shelf arrangement made in libraries withan alternative shelf arrangement? (2)What exposure ofdocuments are there in the various antiquarian bookshops? Isthere anything regarding the exposure that differs betweenthe antiquarian bookshops and the libraries? An idea andideology analysis of various dimensions is used as atheoretical tool during the work. The dimensions were: (1)Shelf arrangement: It is important that customers/borrowerscan find themselves - it is important that staff know wherethe documents are.

This literature review summarizes available data on infection with the parasitic roundworm, Ascaridia galli, as a cause of disease in poultry, including the consequences of a conversion to alternative production systems. Ascaridia galli has a direct life cycle with resistant eggs that survive and are easily spread in the environment, especially in systems with bedding materials where the faecal contact is high. The infection is usually subclinical but depending on the infection dose, the symptoms range from weight loss and diarrhea to mortality. Factors such as the feed composition and genetic variation among different hybrids clearly affect the establishment rate of the infection. Ascaridia galli will probably become an increasing problem, with a shift from the traditional battery cages to alternative systems where the risk of re-infection is high.

Because of increasing demand of power on Malmbanan the capacity of the existing wires which supply the trains must be increased. This increases the stress on the existing poles and for this reason the system for supplying the loads along the railway is to be removed from the poles and be replaced by some other system. This thesis is a study on a two-level low voltage (1 kV and 0.4 kV) electrical system with the aim to investigate if it can be an alternative to the system used today taking into account the voltages, fault currents and costs.In this thesis the following tasks have been performed:? Gathering of data? Description of basic theory? Loadow and fault current calculations of the system with MATLAB? Life Cycle Cost estimate of the system? Analysis and conclusions from the resultsThe results show that the new system can be an alternative to replace today's system. The simulations and calculations show that the voltage drop is at an acceptable level and that the fault currents are large enough to supply a safe disconnection if a fault occurs at the far end of the system..

Den här kandidatuppsatsen behandlar företagsförvärv i sin helhet, med integrationsfasen i fokus.Ett företag som vill vara konkurrenskraftig på dagens dynamiska och intensiva marknader måste överväga företagsförvärv som en del av sin långsiktiga strategiska planering för att kunna uppnå sina mål.Att växa genom företagsförvärv ger många fördelar bl. a. snabbare tillväxthastighet jämfört med enbart organisk tillväxt, den egna organisationen växer och konkurrenternas marknadsandelar krymper.Det är dock inte oproblematiskt att använda sig av företagsförvärv som tillväxtstrategi.Många studier visar att risken är stor att ett företagsförvärv inte lever upp till förväntade resultat som förvärvsorganisation hade i samband med uppköpet.Företagsförvärv omfattar många komplexa delprocesser som kräver en genomtänkt planering och uppföljning.Dock är det en del i förvärvsprocessen som enligt många teoretiker spelar avgörande roll för förvärvets framgång. Den delen av förvärvsprocessen kallas för integrationsfasen och djupet i den här uppsatsen kommer att handla om den fysiska integreringen i samband att Alfa köpte upp Beta.Syftet med den här uppsatsen är att förmedla en ökad förståelse för förvärvsprocessen samt ge en överskådlig bild för hur en förvärvsprocess lämpas i teorin och praktik. Det skall även vara ett verktyg för företaget Alfa vid eventuella framtida företagsförvärv.Studie är av kvalitativ karaktär och byggs på interaktion mellan litteraturstudier inom ämnet företagsförvärv och empirisk data som hämtades in huvudsakligen med hjälp av intervjuer med korrespondenter som jobbar eller har jobbat inom Alfas organisation.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.

This thesis describes possibilities for Metso Paper to lower their costs of spray pipes for their pulp wash press TRPE, with maintained good functionality and quality.Information that can be used by competitors has been censored in this version of the essay.To find solutions, alternative suppliers have been contacted and asked to quote. There has also been a new spray pipe designed. The manufacturing costs of the new design have been calculated.The thesis also contains a concept generation of an alternative product to the spray pipes in installations where a high pressure washer is used.To be able to ask other manufacturers of spray pipes to quote, a demand specification based on the currently used spray pipe was made. This was then sent to two alternative suppliers.An investigation of earlier used spray pipes, and the currently used, shows that the nozzles are a big part of the total costs of the spray pipes. To attempt to reduce the nozzles high cost an concept generation was made to find the best solution for a new design.There was a request that it should be possible to change the internal brushes in the spray pipe without cutting and welding.