Background: Chemotherapy and radiation resistance are major causes of failure in cancer treatment. The response to treatment in cancer cells depends on several mechanisms and pathways such as Janus kinases-signal transducers and activators of transcription JAK/STAT pathway. STAT1 was the first described transcription factor in the STAT family. STAT1 is activated by stimulation of signaling proteins such as type II interferon (IFN- ?) and the activated STAT1 translocates from cytoplasm to nucleus.

This thesis aims to contribute to improved functional procurement of photovoltaic systems, PV systems. Functional procurement means that criteria concerning a function are set rather than specifying technical details or products. Possible advantages and difficulties in using functional procurement have been analyzed by interviews, simulations and a case study. Electricity production and surplus production for different scenarios have been simulated via MATLAB. The MATLAB script was also used to generate rules of thumb on feasible solar fraction for six different load profiles; a church, a farm, a car mechanic, an office, an industry and an apartment building.

This study will focus on the luxury market and how this market has been affected by the present recession. The economic downturn have had a major impact on today?s business and consumption, practically all industries have been affected. However there exist different opinions about how the luxury market have been influenced, certain experts mean that this segment is recession proof while others believe that this market will experience the worst side-effects. For that reason we find it interesting to analyze the luxury market and develop our own opinion about the impact of the recession.

Den senaste FN-rapporten som utfo?rdes av IPCC sa?tter punkt pa? faktumet att katastrofala klimatfo?ra?ndringar kan undvikas utan ma?rkbar inverka pa? levnadsstandarden. Det go?r fo?rnybar energi till den billigaste och minst riskabla va?gen till en fossilfri framtid. Detta motiverar intresset fo?r att underso?ka lo?nsamheten i solcellsanla?ggningar fo?r elna?tinmatning.

Mastitis, inflammation in the udder tissue, caused by S. aureus is a big problem in dairy cattle production. It causes suffering for the cow and curing or replacing the infected cow is costly for the farmer. It is known that beef cattle also suffer from mastitis caused by S. aureus.

The latest thing in the area of environmental building today is energy-plus-house. The idea behind the energy-plus-house is to create a house that produces more energy than it consumes. To accomplish this, the house uses renewable energy, in this particular case solar energy. With the help from a proper construction and thoughtfully projected installations you can achieve a surplus of energy. The surplus energy can then be sold to the surrounding buildings and thereby conduce to a financial profit for the household.

Syndecan-1 is a cell surface proteoglycan which participates in cell adhesion, differentiation, motility, morphogenesis and intracellular signaling. The two glycosaminoglycans heparan sulfate and chondroitin sulfate are covalently attached to the ectodomain of syndecan-1 via a tetra saccharide linkage sequence. However, the ectodomain can be modified having only one or neither of the glycosaminglycans attached. The glycosaminoglycans are capable of binding ligands such as fibroblast growth factors (FGFs) and support activation of receptors. The ectodomain is proteolytically cleaved from the cell surface by metalloproteinases in a process known as shedding.

This study intends to examine the impact of a well known debate page in one of Sweden?s biggest newspapers, Dagens Nyheter. We have done this by analysing Ekot, Aktuellt, Göteborgs Posten and Västerbottens-Kuriren to see to what extent they ?take? news from the debate page.The method used was content analysis and to describe some of our thoughts about how we placed the hits in different categories we chose eight of our hits to exemplify.The material from the newspapers, radio and television was examined to discover the potential impact from the debate page.To carry out this study we have mainly used theories about how media get influenced by each other?s news and how they do follow-ups and refer to the original media. Other theories of importance for our study are for example those about what kinds of events that become news and how media influences people?s thoughts about what?s important.One of the most important conclusions we were able to draw after carrying out our study was that the debate page in Dagens Nyheter has quite a small impact on what our chosen media reported on.

Ocean Thermal Energy Conversion, OTEC, is a sustainable energy conversion technology that is not yet commercialized. OTEC is a technology that utilizes the temperature difference in oceans between the warm surface water and the cold water at 1 000 m depth to run a Rankine Cycle. This technology can produce electricity and provide synergies like fresh water, air conditioning and aquaculture. A simulation program for three alternative OTEC systems has been created in order to decide which OTEC system is most profitable; closed, open or hybrid system. In this simulation a production cost analysis is performed in order to investigate and decide which one of the three systems that has the lowest production cost. The production cost analysis also analyzes if the profitability is affected by the size of the facility. After these analyzes, the most profitable of the three different OTEC-systems is expanded by an installation of solar collectors in order to see if the thermal efficiency is improved. The result shows that the most profitable system varies with the size of the facility.

Promoters are genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

The environmental work in Sweden has developed a lot over the past fifty years. Today, most companies have some kind of environmental work. Environmental activities are regulated by the Environmental Code, which applies in parallel with other laws. This report is an environmental review for Bräcke Diakoni. The report aims to find out how much environmental impact Bräcke Diakoni has.

Modern missiles must meet higher and higher demands. They should be autonomous, have long range and still have a big effect on the target. To maximize effect on target some missiles not only minimize miss distance, but also try to hit with a certain angle; often perpendicular to the surface of the target. In this thesis a method to guide the missile in the terminal phase of its mission where both point of impact as angle of impact are specified. The method consist of two parts.

A large part of Sweden?s green, urban landscape is covered by lawns. Approximately 80 000 ha of maintained grass lawns are part of public courtyards, schoolyards, parks, golf courses, sport fields and traffic environments. Beyond this figure, the lawn is also an essential element in most private villa-gardens. Lawns have become a universal phenomenon through the dispersion of landscape aesthetics from the Western world.

Akademiska hus is a real estate company that specializes in providing Swedish universities with housing facilities for educational and research purposes. The company strives to reduce its use of energy by 40% between the years 2000 and 2025. The aim of this thesis is to determine which measures can be taken to reduce the need of purchased energy in a building that is used by theSwedishUniversityof Agricultural Sciences inUppsala.In order to determine the results of various changes to the building envelope and ventilation system, the building was modelled in the computer simulation program VIP-Energy. Other proposed changes to make the use of energy more efficient concerned water use and lighting. The need of purchased energy can also be reduced by producing electricity or heat on site, using solar energy.Results show that economically viable measures include upgrading windows and faucets, adjusting control systems for ventilation and lighting, and installing roof mounted solar panels for power production.