Antalet läkemedel som lanseras på marknaden har minskat under mer än ett decennium, vilket väcker frågan om huruvida det finns brister i de metoder och resonemang som används vid utvecklingen av ett nytt läkemedel. Syftet i den här litteraturstudien var att utreda delar av frågan kring eventuella brister med hjälp av följande frågeställningar: Vilka in vitro potenser kan man hitta vid en litteratursökning för några på marknaden etablerade humana och/eller veterinära läkemedelssubstanser? Hur förhåller sig in vitro potensen för dessa substanser till den terapeutiska plasmakoncentrationen/det terapeutiska intervallet som har fastställts för dem? Vad finns det i dagsläget för teorier kring eventuella brister i den rådande läkemedelsutvecklingsprocessen? In vitro potens-data för nio etablerade läkemedelssubstanser samlades in och jämfördes med respektive substans terapeutiska plasmakoncentration och en kvot erhölls som sedan relaterades till det resultat som presenterades i en mastersuppsats i farmaci av Fabian Göransson där motsvarande kvot genererades för 150 etablerade läkemedelssubstanser. Det sammanvägda resultatet, med tyngdpunkt på Fabians Göranssons resultat, visar att antagandet att den terapeutiska plasmakoncentrationen är minst tre gånger högre än in vitro potensen kan leda till främst överestimering men också underestimering av den terapeutiska plasmakoncentrationen och att substanser tenderar att vara mer potenta in vivo än in vitro. Därför behövs en högre grad av flexibilitet när ovan nämnda antagande praktiseras under läkemedelsutvecklingsprocessen. Efter en kortare utblick över några teorier kring brister i dagens läkemedelsutvecklingsprocess verkar det som att läkemedelsindustrin behöver revidera samt ifrågasätta lämpligheten hos de principer som idag praktiseras inom området. .

Background: In 1994 came the general prescription law in force for the district nurses with specific training in pharmacology and pathology in Sweden. According to The National Board of Health and Welfare from 2004 follow-up of the use of the prescription law revealed that nearly half of the district nurses used their prescription once a week. According to previous research the district nurses and patients were positive to the district nurses administration of prescriptions. Doctors, contrariwise, were not as favorable to the district nurses administration of prescriptions. The responsibility of the heads of the health centers is to promote the district nurses to prescribe and make sure that it works in a satisfactory manner.

This thesis purpose is to determine an explanation of the efficiency in a labour-market related project. ?Enter? is an EU-financed project with a focus on long-term unemployed workers in the district Härlanda, Gothenburg. Starting in September 2004, Enter offers individually based coaching and job guidance to totally 110 young persons with problems entering the labour market. The goal is to provide these people courage to find either full or part time employment or to start study.

Our employer Camatec Industriteknik AB gave us the assignments to increase theirs range of versions on Camcoil that is their own patent product. Camcoil is a capstan system that is used when steel band fabricated. Exist for example in production lines their steel band should be annealed. Our goal with this work is to come up with a completed production basis on a Camcoil for heavy industry. The basis should contain calculations, 3D-constructions, drawings and cost proposal on manufacturing and detail purchase.Demands on this project:1.

Pyometra is a common and life threatening disease of intact bitches. The disease is caused by a hormonal influence on the uterus in combination with a bacterial infection. The most common treatment is ovariohysterectomy, but several medical options are available to maintain fertility or avoid surgery and anaesthesia. Drugs that can be used for medical treatment are for example progesterone-receptor antagonists, prostaglandins and dopamine agonist. The present study focused on treatment with the progesterone-receptor antagonistaglepristone in combination with antimicrobial therapy.

Varje år placeras över 1000 ungdomar inom Statens Institutions Styrelse (SiS), varav ungefär hälften placeras för behandling. Studiens frågeställningar är: I vilken grad uppfattar behandlingsplacerade ungdomar inom SiS att de får hjälp med sina familjeproblem? Finns det synliga samband mellan ungdomarnas könstillhörighet eller etniska ursprung och deras skattade upplevelse av hjälp med familjeproblem under placeringstiden? För att besvara frågorna har kvantitativ arkivdata analyserats, material som vid in- och utskrivning av ungdomar samlats genom strukturerade ADAD-intervjuer (Adolescent Drug Abuse Diagnosis). Studien visar att ungdomarnas upplevelse av hjälp kan delas in i tre kategorier; ?över förväntan? 27%, ?motsvarar förväntan? 41%, ?mindre än förväntat?, 32%.

EU direktiv 2005/0182 röstades igenom i början av år 2006. All trafik-data kring Internet- och telekommunikation ska lagras mellan sex må-nader och ett år. Direktivet kommer innebära gemensamma regler för EU:s medlemsstater. Syftet med direktivet är att data ska lagras för till-gänglig vid utredning, avslöjande och åtal av grov organiserad brottslig-het och terrorism.Studien innehåller tre problemområden som behandlar andra gällande direktiv och konventioner, personlig integritet och etik. Först undersöks det nya direktivet i relation till European Convention on human rights (ECHR) Vidare förs diskussioner kring lagring av trafikdata och lokali-seringsdata i förhållande till personlig integritet.

The castration of piglets is performed routinely all around the world. Most castrations are done without anaesthesia and analgesia, despite the fact that this procedure has been proved to induce acute pain and stress for the piglets. The procedure regarding castration of piglets is currently a hot topic of debate and an important political issue. The underlying issue is the boar taint which are highlighted in the heating of the meat after slaughter, which in turn can lead to reduced meat sales as it can be perceived as unpleasant for many consumers. The purpose of this study is to examine alternative drugs which may be selected in order to replace the practice of castration of piglets without anaesthesia, in light of improved animal welfare.

Canine dilated cardiomyopathy (DCM) is a disease with high morbidity and mortality and with a high prevalence in certain breeds. Predominatly large breeds are affected, such as Great danes, Newfoundlands, Deerhounds and Dobermanns. One exception is Cocker spaniels, where both American and English Cocker spaniels are affected in a quite high frequency. Cardiomyopathy is characterised as a disease that affects the myocardium and gives an impaired heart function. To diagnose DCM following criteria have to be observed: 1. Dilation of the left ventricle. 2. Reduced systolic heart function. 3. Increased sphericity of the left ventricle. To be certain of the diagnosis, alternative reasons for the symptoms such as lung- and heart diseases with other etiologies have to be excluded Two different types of DCM have been found upon histological examination.

This thesis concerns the Gotlandic hill-forts (sw. fornborg) situated on a cliff or in an elevated position and which traditionally have been referred to as cliff-forts (sw. klintborg/höjdborg). The study derives from the notion that these monuments, diverse in size and shape, by archaeologists have been viewed and treated as a homogeneous category of ancient remains. The author?s key aim is to challenge this perception by identifying various subcategories from the 28 cliff-forts on the island.Ever since the archaeological discipline initiated the study of cliff-forts in the late 1800s and more or less to present day, the interpretations have been almost solely dominated by explanations of the military and defendable nature of them.

Malaria är en farlig tropiksjukdom orsakad av parasiten Plasmodium som vållar många dödsfall varje år. Sedan några år tillbaka rekommenderar Världshälsoorganisationen (WHO) användandet av artemisinin och dess derivat för behandlandet av malaria. Artemisinin syntetiseras normalt i växten Artemisia annua i lågt utbyte. På grund av det låga utbytet är läkemedlet väldigt dyrt. Då parasiten blivit resistent mot de flesta malarialäkemedel är artemisinin ett viktigt preparat i kampen mot malaria.

This thesis, designed as a case study, is about complications concerning conservation of a decorative oil paint on lime plaster from the drawing-room in Mostorp castle sited in the county of Halland in south-west of Sweden. The building was built 1878-80 with an exterior of granite. The interior walls were made of clay bricks, lime mortar and lime plaster. The oil paint is applied to a layer of putty. The combination of different materials, which are organic and inorganic, affects the movement caused by internal and external stress.

The interest in horses and equestrian sport is constantly increasing, and so is the will in both riders and trainers to learn more about the effect the rider and its equipment have on the horse. The last twenty years, more and more studies have been performed were the horse and its kinematics have been in focus. The access to more advanced technology has made it possible to study areas, which earlier have been hard to reach. The knowledge about kinematics in the horse, and how riders and their equipment interact with the horse?s movement, is also of great interest to veterinarians in equine practice.

So- called ?Network Based Defense? (NBD) was introduced in Sweden in connection with the transformation of the Swedish Armed Forces in 1999. NBD is based on the U.S. variant Network Centric Warfare (NCW), which in turn is derived from research on the concept of Revolution in Military Affairs (RMA). In Sweden the concept was introduced and included not only the Armed Forces but was intended to also support the Swedish civilian agencies in order to create networks and hence share the available information and thus more effective crisis management and to provide more "bang for the buck." In developing the concept of NBD the Swedish Armed Forces used both economic and human resources, in the form of research, new technologies, new organization and new methods.Between year 2004 and 2006 the Armed Forces once again entered the process of reorganization.

The Nord Stream natural gas pipeline has been a controversial project. The debate was primarily escalated by Poland's strong negative reaction to the project in the spring of 2006 over safety and security and then alternated back and forth in Europe until the approval by the nations most concerned in the Baltic region during the autumn of 2009.In the case study an approach is used that primarily maps out the media image of the various viewpoints that deal with the pipeline and how these viewpoints position themselves, primarily through political and environmental dimensions. Simultaneously there?s an attempt to map out the spatial spread of the media image views as to the proximity and distance to the pipeline in Sweden, Poland and Germany. A key question is whether distance or proximity to a large facility can affect people's attitudes.A parallel focus of the study is to explore the role of the Nord Stream natural gas pipeline in the cross-border hinterland region of Szczecin-?winouj?cie.