Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

Hösten 1753 utlyste drottning Lovisa Ulrikas Witterhetsakademi en tävling där de deltagande skulle skriva om ett (eller flera) av tre ämnen: en historisk uppsats på prosa, en skönlitterär behandling på prosa, och ett ?Poeme öfwer Konung Carl Gustafs Tåg med sin Krigshär öfwer Bälterna år 1658?. Ett av de bidrag som kom in till tävlingen, om än för sent för att delta, var Hedvig Charlotta Nordenflychts bidrag Konung Carl Gustafs tog öfwer Bält 1658.1 Hedvig Charlotta Nordenflycht var 1700-talets mest kända kvinnliga författare och känd för bland annat Den sörjande Turtur-Duvan, Fruentimrets försvar och Tankar om lovskrifter över de Döde, men allt hon skrev har inte fallit litteraturhistorikerna på läppen. Ett sådant exempel är Konung Carl Gustafs tog öfwer Bält, som sågats ganska grundligt..

Wound care of the horse?s distal part of the leg is challenging. Due to that distal limb wounds are easily enlarged, infected and generally heal slower than wounds on the body of the horse, the need for improved wound nursing arise. One way of improving wound nursing is to evaluate new ways of healing treatment. In this study, evaluation was made of a new product consisting of lactic acid bacteria and honey.

The acid deposition of sulphur- and nitrogenoxides from combustion of coal and oil cause acidification that lowers pH and gives increased contents of metals and altered aquatic biodiversity in the stream. The liming of lakes and streams, which was introduced to resist the acidification, demand large economic resourses despite of the decreased deposition of the acidifyng substances. Some of the streams are influenced by the acid deposition, while others are naturally acidic. It is therefore importaint to separate the anthropogenically acidified waters from the naturally acidic, in order to optimize the use of governmental fundings for liming. This thesis aims to estimate the acidity status and impact of acidification on 24 catchments upstream liming dispensers, which is part of the liming activities at the County of Dalarna.The acidity status of the streams was classified according to the Swedish Environmental Protection Agency old classification system (Naturvårdsverket 1999) as very acid to acid, with small ability to withstand a pH-change (alkalinity) due to acid deposition.

This Master Thesis is a product development project that has been carried out incooperation with Metso Paper Sundsvall AB. The task has been to develop a holdingsolution that generates force between two rolls and to evaluate the new solution withrespect to functionality, manufacturing, structural stability, costs, assembly etc. Theroll holding solution is a system that is part of a rollpress. The rollpress is used towash and dewater pulp. The existing solution creates forces that have to be absorbedby the gable of the press.

Chinas government has a multifunctional program for a more sustainable forestry since 2000. This six key forest programs goal is to develop a more sustainable forest sector but also take environment consideration. The state forest administration in China has decided to create 5.8 million hectare of fast growing and high yield forest. Eucalyptus has showed to have good properties for pulp and timber production and therefore Eucalyptus plantations are under development in costal areas in southern China. By adding extra nutrients, growth can be enhanced in Eucalyptus plantations.

Several diseases increase the risk of thrombosis in dogs and cats, often with a fatal outcome. Currently there are no definite treatment guidelines for the use of thrombolytic and thromboprofylactic agents in veterinary medicine. None of these drugs are approved for dogs and cats in Sweden. Medicines aimed for humans have been used tentatively. This literature study is an investigation of what is currently known about the effects and safety of these pharmacological agents when used for dogs and cats.

Husums plant has a selection of different pulp pumps at bleaching plant 4 and 5. The displacement- (HC-pump, Sund Defibrator PTD-60) and centrifugalpumps (MC-pump, MCA 42-200, MCP 30/20) are of interest in this report. The centrifugal pumps are controlled by throttle valves, which result in an energy loss. Chemical mixers are used to mix ClO2 into the pulp before proceeding into a holding tower where the bleaching process occurs.The energy demand of the different positions has been measured or calculated to be used in comparisons against new equipment. Quotations were requested and delivered from Valmet and Sulzer.

Ten cows suffering from displacement of abomasum (DA) were treated with two different electrolytesolutions. The DA cows showed symptoms typical for the disease. Four out of 10 cows had a metabolic alkalosis and two a metabolic acidosis. The cows were mildly hypocalcemic, and 9 out of 10 were mildly to moderately hypokalemic. Six out of 10 cows showed muscle fasciculations.

An analysis of a specific application of anaerobic wastewater treatment at a pulp and board mill, Stora Enso Skoghall, was carried out. A literature study was done and effluent wastewater from CTMP pulp production was analyzed. The analysis consisted of a broad constituent analysis and an anaerobic treatment trial. Results from these test where used to calculate the treatment effectiveness and resulting energy potential at the mill.The literature study and constituent analysis showed that toxicity of the water to be treated, due to wood extractives and sulphur content, was of concern. Detoxification chemicals targeting these constituents where used in the anaerobic treatment trial.

Benchmarking is an established method of working which is often used in order to develop the quality of the organization. However, almost 70% of the organizations with benchmarking fail due to the lack of planning and structuring of the benchmarking exercise. Maintenance sections in the paper and pulp industry are one of those who have decided to conduct benchmarking. Therefore, the purpose of this study is to gain knowledge of how the maintenance sections in the paper and pulp industry deliberately structure and plan to use benchmarking as a driving force for quality development in the maintenance sections.The study is a hermeneutic case study. Telephone interviews and document analysis have been used as data acquisition methods.The results show that there is a lack of both planning and structuring in the benchmarking process, and lack of management commitment for quality improvements within industrial maintenance.

Benchmarking is an established method of working which is often used in order to develop the quality of the organization. However, almost 70% of the organizations with benchmarking fail due to the lack of planning and structuring of the benchmarking exercise. Maintenance sections in the paper and pulp industry are one of those who have decided to conduct benchmarking. Therefore, the purpose of this study is to gain knowledge of how the maintenance sections in the paper and pulp industry deliberately structure and plan to use benchmarking as a driving force for quality development in the maintenance sections.The study is a hermeneutic case study. Telephone interviews and document analysis have been used as data acquisition methods.The results show that there is a lack of both planning and structuring in the benchmarking process, and lack of management commitment for quality improvements within industrial maintenance.

An analysis of a specific application of anaerobic wastewater treatment at a pulp and board mill, Stora Enso Skoghall, was carried out. A literature study was done and effluent wastewater from CTMP pulp production was analyzed. The analysis consisted of a broad constituent analysis and an anaerobic treatment trial. Results from these test where used to calculate the treatment effectiveness and resulting energy potential at the mill.The literature study and constituent analysis showed that toxicity of the water to be treated, due to wood extractives and sulphur content, was of concern. Detoxification chemicals targeting these constituents where used in the anaerobic treatment trial.

The objective of the present study was to evaluate distillers? dried grains with solubles (DDGS) as a protein source to rainbow trout (Oncorhynchus mykiss), by studying digestibility and growth measurements. One control diet, totally lacking DDGS, and three test diets were made containing 10 % (low), 31% (medium) and 51 % (high) DDGS respectively on dry matter (DM) basis. The control diet and the test diets were made to be as nutritionally equal as possible. Wheat bran was used to balance the fiber content of the diets.

Since the 19th century the concentration of CO2 in the atmosphere hasincreased by 40 percent as an effect of the use of fossil energy sources.Increased concentration of CO2 will likely lead to increased temperature,changes in precipitation, rising sea level and increased frequency of extremeweather like storm events. A step to reduce emissions of CO2 and mitigateclimate change, for the property of Tagel, can be to adopt new silviculturalstrategies and analyse which is the most effective. As a result of that, threescenarios was produced, business-as-usual (BAU), increased set aside landand energy. An introduction of windpower at Tagels estate (property) andeffects on carbon balance was also examined. By using the Heureka systemand LCA-analysis in this study, it showed that the scenario of increased setaside land was the most efficient way to reduce carbon dioxide (CO2)emissions for the analysed period of 100 years.